Ages 40-64 Years: Laboratory and Other Tests


Cervical cytology 

Preferred: Co-test with cytology and HPV testing every 5 years

Option: Screen with cytology alone every 3 years

Colorectal cancer screening (beginning at age 50 years: colonoscopy every 10 years [preferred])

Other methods include: 

  1. Fecal occult blood testing or fecal immunochemical test, annual patient-collected (each method requires two or three samples of stool collected by the patient at home and returned for analysis. A single stool sample obtained by digital rectal examination is not adequate for the detection of colorectal cancer.)
  2. Flexible sigmoidoscopy every 5 years
  3. Double contrast barium enema every 5 years
  4. Computed tomography colonography every 5 years
  5. Stool DNA

The American College of Gastroenterology recommends that African Americans begin screening at age 45 years with colonoscopy because of increased incidence and earlier age of onset of colorectal cancer.

Diabetes testing (every 3 years after age 45 years)

Hepatitis C virus testing (one-time testing for persons born from 1945 through 1965 and unaware of their infection status)

Human immunodeficiency virus (HIV) testing  (Physicians should be aware of and follow  their states' HIV screening requirements. Visit the Centers for Disease Control and  Prevention for more information.)
Lipid profile assessment (every 5 years beginning at age 45 years)
Mammography (yearly)
Thyroid-stimulating hormone testing (every 5 years beginning at age 50 years)

High-Risk Groups (See High-Risk Table for more information.)

Bone mineral density screening
Colorectal cancer screening
Diabetes testing

Hemoglobin level assessment
Lipid profile assessment
Sexually transmitted infection testing
Thyroid-stimulating hormone testing
Tuberculosis skin testing